Efficient Copper-Catalyzed Benzylic Amidation with Anhydrous Chloramine-T

Ranjana Bhuyan and Kenneth M. Nicholas*

*Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, Email: knicholasou.edu

R. Bhuyan, K. M. Nicholas, Org. Lett., 2007, 9, 3957-3959.

DOI: 10.1021/ol701544z

---

see article for more reactions

Abstract

Benzylic hydrocarbons are selectively converted to the corresponding sulfonamides by the [Cu(CH₃CN)₄]PF₆-catalyzed reaction with anhydrous TolSO₂NNaCl (chloramine-T). Under the same conditions, representative ethers and olefins are also amidated.

see article for more examples

---

---

Key Words

Protected Primary Amines, Benzylic Amines, Sulfonamides, Chloramin-T

---

ID: J54-Y2007-3100