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Highly Efficient O-Silylation of Alcohol with Vinylsilane Using a Rh(I)/HCl Catalyst at Room Temperature

Jung-Woo Park and Chul-Ho Jun*

*Department of Chemistry and Centre for Bioactive Molecular Hybrid (CBMH), Yonsei University, Seoul 120-749, Korea, Email:

J.-W. Park, C.-H. Jun, Org. Lett., 2007, 9, 4073-4076.

DOI: 10.1021/ol701909e (free Supporting Information)


A key intermediate in a highly efficient rhodium-catalyzed O-silylation of alcohols is chlorosilane, generated from vinylsilane and HCl, which is regenerated in the catalytic cycle. Various alcohols and vinylsilanes were applied to the preparation of silyl ethers with this catalyst system.

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Key Words

Silyl Ethers

ID: J54-Y2007-3150