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Mild and Efficient Indium Metal Catalyzed Synthesis of Sulfonamides and Sulfonic Esters

Joong-Gon Kim, Doo Ok Jang*

*Department of Chemistry, Yonsei University, Wonju 220710, South Korea, Email:

J. Yan, J. Li, D. Cheng, Synlett, 2007, 2501-2504.

DOI: 10.1055/s-2007-986632


A facile and efficient indium-catalyzed sulfonylation of amines allows the synthesis of a wide range of sulfonamides in excellent yields. The method showed a generality for substrates including less nucleophilic and sterically hindered anilines, and it is also applicable for preparing sulfonic esters from sulfonyl chlorides and alcohols.

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Key Words

sulfonylation, indium, sulfonamides, sulfonic esters, sulfonyl chlorides, toluenesulfonamides

ID: J60-Y2007-3180