Organic Chemistry Portal



Cobalt-Catalyzed Reductive Coupling of Activated Alkenes with Alkynes

Hong-Tai Chang, Thiruvellore Thatai Jayanth, Chun-Chih Wang and Chien-Hong Cheng*

*Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, Email:

H.-T. Chang, T. T. Jayanth, C.-C. Wang, C.-H. Cheng, J. Am. Chem. Soc., 2007, 129, 12032-12041.

DOI: 10.1021/ja073604c

see article for more reactions


Cobalt complex/Zn systems effectively catalyze the reductive coupling of activated alkenes with alkynes in the presence of water to give substituted alkenes with very high regio- and stereoselectivity in excellent yields.

see article for more examples

Key Words

Carbonyl Compounds, Alkenes, Cyclopentanes, Zinc

ID: J48-Y2007-3190