A new one-step synthesis of pyridines under microwave-assisted conditions
Mark C. Bagley*, Rebecca Lunn and Xin Xiong
*Department of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK, Email: bagleymccf.ac.uk
M. C. Bagley, R. Lunn, X. Xiong, Tetrahedron Lett., 2002, 43, 8331-8334.
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Tri- or tetrasubstituted pyridines are prepared by microwave irradiation of ethyl β-aminocrotonate and various alkynones in a single synthetic step and with total control of regiochemistry. This new one-pot Bohlmann-Rahtz procedure conducted at 170°C gives superior yields to similar experiments conducted using conductive-heating techniques in a sealed tube.
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X. Xiong, M. C. Bagley, K. Chapaneri, Tetrahedron Lett., 2004, 45, 6121-6124.
M. C. Bagley, J. W. Dale, J. Bower, Synlett, 2001, 1149-1151.