Electrochemically Induced Aza-Henry Reaction: A New, Mild, and Clean Synthesis of α-Nitroamines

Leucio Rossi*, Gabriele Bianchi, Marta Feroci, Achille Inesi

*Dipartimento di Chimica, Ingegneria Chimica e Materiali, Universita degli Studi, 67040 L'Aquila, Italy, Email: leucio.rossiing.univaq.it

L. Rossi, G. Bianchi, M. Feroci, A. Inesi, Synlett, 2007, 2505-2508.

DOI: 10.1055/s-2007-986643

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Abstract

The aza-Henry reaction of nitro compounds to azomethine functions was performed electrochemically under solvent and supporting electrolyte-free conditions. Reaction yields are very good and the method is very clean, avoiding the use of any classical solvent or catalyst.

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Electrochemically Promoted C-N Bond Formation from Amines and CO₂ in Ionic Liquid BMIm-BF₄: Synthesis of Carbamates

M. Feroci, M. Orsini, L. Rossi, G. Sotgiu, A. Inesi, J. Org. Chem., 2007, 72, 144-149.

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Key Words

carbanions, green chemistry, imines, Henry reaction, Michael addition, nucleophilic additions, electrochemistry

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ID: J60-Y2007-3240