Organic Chemistry Portal



Electrochemically Induced Aza-Henry Reaction: A New, Mild, and Clean Synthesis of α-Nitroamines

Leucio Rossi*, Gabriele Bianchi, Marta Feroci, Achille Inesi

*Dipartimento di Chimica, Ingegneria Chimica e Materiali, Universita degli Studi, 67040 L'Aquila, Italy, Email:

L. Rossi, G. Bianchi, M. Feroci, A. Inesi, Synlett, 2007, 2505-2508.

DOI: 10.1055/s-2007-986643


The aza-Henry reaction of nitro compounds to azomethine functions was performed electrochemically under solvent and supporting electrolyte-free conditions. Reaction yields are very good and the method is very clean, avoiding the use of any classical solvent or catalyst.

see article for more examples

Electrochemically Promoted C-N Bond Formation from Amines and CO2 in Ionic Liquid BMIm-BF4: Synthesis of Carbamates

M. Feroci, M. Orsini, L. Rossi, G. Sotgiu, A. Inesi, J. Org. Chem., 2007, 72, 144-149.

Key Words

carbanions, green chemistry, imines, Henry reaction, Michael addition, nucleophilic additions, electrochemistry

ID: J60-Y2007-3240