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A new mild method for the one-pot synthesis of pyridines

Xin Xiong, Mark C Bagley and Krishna Chapaneri

*Department of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK, Email:

X. Xiong, M. C. Bagley, K. Chapaneri, Tetrahedron Lett., 2004, 45, 6121-6124.

DOI: 10.1016/j.tetlet.2004.06.061

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Polysubstituted pyridines are prepared in good yield and with total regiocontrol by the one-pot reaction of an alkynone, 1,3-dicarbonyl compound and ammonium acetate in alcoholic solvents. This new three-component heteroannulation reaction proceeds under mild conditions in the absence of an additional acid catalyst.

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proposed reaction pathway

A new one-step synthesis of pyridines under microwave-assisted conditions

M. C. Bagley, R. Lunn, X. Xiong, Tetrahedron Lett., 2002, 43, 8331-8334.

A New Modification of the Bohlmann-Rahtz Pyridine Synthesis

M. C. Bagley, J. W. Dale, J. Bower, Synlett, 2001, 1149-1151.

Key Words

Pyridines, Multicomponent Reactions, Heterocycles, Bohlmann-Rahtz Pyridine Synthesis

ID: J72-Y2004-2490