A new mild method for the one-pot synthesis of pyridines
Xin Xiong, Mark C Bagley and Krishna Chapaneri
*Department of Chemistry, Cardiff University, Park Place, Cardiff, CF10 3AT, UK, Email: bagleymccf.ac.uk
X. Xiong, M. C. Bagley, K. Chapaneri, Tetrahedron Lett., 2004, 45, 6121-6124.
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Polysubstituted pyridines are prepared in good yield and with total regiocontrol by the one-pot reaction of an alkynone, 1,3-dicarbonyl compound and ammonium acetate in alcoholic solvents. This new three-component heteroannulation reaction proceeds under mild conditions in the absence of an additional acid catalyst.
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proposed reaction pathway
M. C. Bagley, R. Lunn, X. Xiong, Tetrahedron Lett., 2002, 43, 8331-8334.
M. C. Bagley, J. W. Dale, J. Bower, Synlett, 2001, 1149-1151.