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Gold-Catalyzed Multicomponent Synthesis of Aminoindolizines from Aldehydes, Amines, and Alkynes under Solvent-Free Conditions or in Water

Bin Yan and Yuanhong Liu*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email:

B. Yan, Y. Liu, Org. Lett., 2007, 9, 4323-4326.

DOI: 10.1021/ol701886e


A gold(III)-catalyzed multicomponent coupling/cycloisomerization reaction of heteroaryl aldehydes, amines, and alkynes under solvent-free conditions or in water provides rapid access to substituted aminoindolizines with high atom economy and high catalytic efficiency.

see article for more examples

proposed mechanism

General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions

Y. Liu, Z. Song, B. Yan, Org. Lett., 2007, 9, 409-412.

Highly Efficient Synthesis of Functionalized Indolizines and Indolizinones by Copper-Catalyzed Cycloisomerizations of Propargylic Pyridines

B. Yan, Y. Zhou, H. Zhang, J. Chen, Y. Liu, J. Org. Chem., 2007, 72, 7783-7786.

Key Words

Indolizines, Multicomponent Reactions, Green Chemistry

ID: J54-Y2007-3250