Copper-Catalyzed Arylation of Heterocycle C-H Bonds
Hien-Quang Do and Olafs Daugulis*
*Department of Chemistry, University of Houston, Houston,
Texas 77204-5003, Email: olafs
uh.edu
H.-Q. Do, O. Daugulis, J. Am. Chem. Soc., 2007, 129, 12404-12405.
DOI: 10.1021/ja075802+ (free Supporting Information)
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Abstract
A new method for a direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl iodides allows the conversion of electron-rich five-membered heterocycles and electron-poor pyridine oxides. The best results are obtained by using a combination of lithium tert-butoxide as base and copper iodide as catalyst.
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A General Method for Copper-Catalyzed Arylation of Arene C-H Bonds
H.-Q. Do, R. M. K. Khan, O. Daugulis, J. Am. Chem. Soc., 2008, 129, 15185-15192. DOI: 10.1021/ja805688p
Key Words
Arylation, Oxazoles, Benzoxazoles, Thiazoles
ID: J48-Y2007-3330
