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Copper-Catalyzed Arylation of Heterocycle C-H Bonds

Hien-Quang Do and Olafs Daugulis*

*Department of Chemistry, University of Houston, Houston, Texas 77204-5003, Email:

H.-Q. Do, O. Daugulis, J. Am. Chem. Soc., 2007, 129, 12404-12405.

DOI: 10.1021/ja075802+

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A new method for a direct, copper-catalyzed arylation of heterocycle C-H bonds by aryl iodides allows the conversion of electron-rich five-membered heterocycles and electron-poor pyridine oxides. The best results are obtained by using a combination of lithium tert-butoxide as base and copper iodide as catalyst.

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A General Method for Copper-Catalyzed Arylation of Arene C-H Bonds

H.-Q. Do, R. M. K. Khan, O. Daugulis, J. Am. Chem. Soc., 2008, 129, 15185-15192. DOI: 10.1021/ja805688p

Key Words

Arylation, Oxazoles, Benzoxazoles, Thiazoles

ID: J48-Y2007-3330