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An Improved Procedure for the Preparation of Acetals from Diaryl Ketones

Andrew Thurkauf, Arthur E. Jacobson, Kenner C. Rice*

*National Institutes of Health, Building 8, Room B122, Bethesda, MD 20892, USA, Email:

A. Thurkauf, A. E. Jacobson, K. C. Rice, Synthesis, 1988, 233-234.

DOI: 10.1055/s-1988-27525


Acetals of diaryl ketones with nitro, halo and methoxy substituents are easily prepared in high yield by treatment with an alcohol and the corresponding trialkyl orthoformate in the presence of a catalytic amount of trifluoromethanesulfonic acid.

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Key Words

acetals, dimethyl acetals

ID: J66-Y1988-120