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Aminocarbonylation of Aryl Halides Using a Nickel Phosphite Catalytic System

Jinhun Ju, Miso Jeong, Jeongju Moon, Hyun Min Jung and Sunwoo Lee*

*Department of Chemistry, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju 500-757, Republic of Korea, Email: sunwoochonnam.ac.kr

J. Ju, M. Jeong, J. Moon, H. M. Jung, S. Lee, Org. Lett., 2007, 9, 4615-4618.

DOI: 10.1021/ol702058e (free Supporting Information)


Abstract

Nickel catalysis enables a very efficient aminocarbonylation reaction to be performed between aryl iodides or bromides and N,N-dimethylformamide (DMF) in the presence of sodium methoxide and a phosphite ligand, which is very stable to air and moisture and, furthermore, inexpensive.

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Key Words

Aminocarbonylation


ID: J54-Y2007-3490