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Microwave-Assisted Transformation of Esters into Hydroxamic Acids

Assunta Massaro, Alessandro Mordini*, Gianna Reginato, Francesco Russo, Maurizio Taddei

*ICCOM-CNR, Dipartimento di Chimica Organica ‘U. Schiff', Via della Lastruccia 13, 50019 Sesto Fiorentino, Italy, Email:

A. Massaro, A. Mordini, G. Reginato, F. Russo, M. Taddei, Synthesis, 2007, 3201-3204.

DOI: 10.1055/s-2007-990803


The reaction of esters with hydroxylamine in the presence of a base under microwave activation provides hydroxamic acids in good yields and purity. The method has been successfully applied to enantiomerically pure esters without loss of stereochemical integrity.

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Key Words

esters, chemoselectivity, hydroxamic acids, microwave reactions

ID: J66-Y2007-3490