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AuCl-Catalyzed Synthesis of Benzyl-Protected Substituted Phenols: A Formal [3+3] Approach

Xiaogen Huang and Liming Zhang*

*Department of Chemistry, University of Nevada, Reno, Nevada 89557, Email:

X. Huang, L. Zhang, Org. Lett., 2007, 9, 4627-4630.

DOI: 10.1021/ol7021356 (free Supporting Information)


A AuCl-catalyzed, flexible synthesis of highly substituted, benzyl-protected phenols unites enal/enones and benzyl allenyl ethers in a [3+3] fashion in two steps, allowing excellent control of substitution at the benzene ring.

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Key Words

Allenes, Cyclization, Indanes

ID: J54-Y2007-3500