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Application of β-Hydroxysulfoximines in Catalytic Asymmetric Phenyl Transfer Reactions for the Synthesis of Diarylmethanols

Jörg Sedelmeier and Carsten Bolm*

*Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany, Email: carsten.bolmoc.rwth-aachen.de

J. Sedelmeier, C. Bolm, J. Org. Chem., 2007, 72, 8859-8862.

DOI: 10.1021/jo7016718 (free Supporting Information)


Abstract

Enantiomerically enriched diarylmethanols have been prepared by catalyzed asymmetric phenyl transfer reactions onto aromatic aldehydes with use of readily available β-hydroxysulfoximines as catalysts. Various functionalized aldehydes and heterocyclic substrates are tolerated, yielding synthetically relevant products.

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Key Words

Diarylmethanols


ID: J42-Y2007-3540