Novel and Facile Transformation of N,N-Disubstituted Glycylamides into Corresponding Cyanamides by Using Pentavalent Iodine Reagents in Combination with Tetraethylammonium Bromide
Kiran H. Chaudhari, Ulhas S. Mahajan, Dinesh S. Bhalerao, Krishnacharya G. Akamanchi*
*Department of Pharmaceutical Sciences & Technology,
Institute of Chemical Technology, Matunga, Mumbai 400 019, India, Email: kgaprediffmail.com
K. H. Chaudhari, U. S. Mahajan, D. S. Bhalerao, K. G. Akamanchi, Synlett, 2007, 2815-2818.
DOI: 10.1055/s-2007-991093
Abstract
A novel and facile transformation of N,N-disubstituted glycylamides into corresponding cyanamides using pentavalent iodine reagents and tetraethylammonium bromide offers advantages such as use of non toxic reagents, shorter reaction times and good yields.
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D. S. Bhalarao, U. S. Mahajan, K. H. Chaudhari, K. G. Akamanchi, J. Org. Chem., 2007, 72, 662-665.
Key Words
pentavalent iodine reagents, o-iodoxybenzoic acid, Dess-Martin periodinane, tetraethylammonium bromide, glycylamides, cyanamides
ID: J60-Y2007-3620