Organic Chemistry Portal



Aqueous-Phase One-Pot Synthesis of 2-Aminothiazole- or 2-Aminoselenazole-5-carboxylates from β-Keto Esters, Thiourea or Selenourea, and N-Bromo-succinimide under Supramolecular Catalysis

Mendu Narender, Majjigapu Somi Reddy, Vydyula Pavan Kumar, Boga Srinivas, Regati Sridhar, Yadavalli Venkata Durga Nageswar, Kakulapati Rama Rao*

*Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

M. Narender, M. S. Reddy, V. P. Kumar, B. Srinivas, R. Sridhar, Y. V. D. Nageswar, K. R. Rao, Synthesis, 2007, 3469-3472.

DOI: 10.1055/s-2007-990849

see article for more reactions


2-Amino-4-alkyl- and 2-amino-4-arylthiazole-5-carboxylates and their selenazole analogues were synthesized by α-halogenation of β-keto esters with N-bromosuccinimide, followed by cyclization with thiourea or selenourea, respectively, in the presence of β-cyclodextrin in water at 50C.

see article for more examples

Key Words

thiazoles, selenazoles, β-keto esters, N-bromosuccinimide, cyclodextrins

ID: J66-Y2007-3640