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A Simple and Efficient Procedure of Low Valent Iron- or Copper-Mediated Reformatsky Reaction of Aldehydes

Angshuman Chattopadhyay* and Akhil Kr. Dubey

*Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai-400 085, India, Email:

A. Chattopadhyay, A. Kr. Dubey, J. Org. Chem., 2007, 72, 9357-9359.

DOI: 10.1021/jo0710984

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An operationally simple and very efficient Reformatsky reaction of aldehydes has been carried out in THF in the presence of low valent iron or copper which were prepared in situ employing a bimetal redox strategy through reduction of Fe(III) or Cu(II) salts with magnesium.

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Key Words

Reformatsky Reaction, magnesium, low valent iron

ID: J42-Y2007-3730