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An Improved One-pot Procedure for the Synthesis of Alkynes from Aldehydes

Stephan Müller, Bernd Liepold, Gerald J. Roth*, Hans Jürgen Bestmann

*Institut für Organische Chemie der Universität Erlangen-Nürnberg, Henkestraße 42, D-91054 Erlangen, Germany, Email:

S. Müller, B. Liepold, G. J. Roth, H. J. Bestmann, Synlett, 1996, 521-522.

DOI: 10.1055/s-1996-5474


The transformation of aldehydes to terminal alkynes can be achieved with dimethyl-1-diazo-2-oxopropylphosphonate. This mild one-pot procedure allows the isolation of the products in good to excellent yields without requiring low temperatures or inert gas techniques and avoiding the use of strong bases.

see article for more examples

Further Improvements of the Synthesis of Alkynes from Aldehydes

G. J. Roth, B. Liepold, S. G. Müller, H. J. Bestmann, Synthesis, 2004, 59-62.

Key Words

aldehydes, alkynes, Seyferth-Gilbert Homologation, dimethyl-1-diazo-2-oxopropylphosphonate, Bestmann-Ohira Reagent

ID: J60-Y1996-660