Carbonylative Ring Opening of Terminal Epoxides at Atmospheric Pressure
Scott E. Denmark* and Moballigh Ahmad
*Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801 Email: denmarkscs.uiuc.edu
S. E. Denmark, M. Ahmad, J. Org. Chem., 2007, 72, 9630-9634.
A mild, Co2(CO)8-catalyzed carbonylative opening of terminal epoxides under 1 atm of carbon monoxide at room temperature in methanol provides β-hydroxy esters in good yields. This transformation tolerates various functional groups.
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