Carbonylative Ring Opening of Terminal Epoxides at Atmospheric Pressure
Scott E. Denmark* and Moballigh Ahmad
*Roger Adams Laboratory, Department of Chemistry, University
of Illinois, Urbana, Illinois 61801
Email: denmarkscs.uiuc.edu
S. E. Denmark, M. Ahmad, J. Org. Chem., 2007, 72, 9630-9634.
DOI: 10.1021/jo7014455
Abstract
A mild, Co2(CO)8-catalyzed carbonylative opening of terminal epoxides under 1 atm of carbon monoxide at room temperature in methanol provides β-hydroxy esters in good yields. This transformation tolerates various functional groups.
see article for more examples
Key Words
carboxylations, β-hydroxy esters
ID: J42-Y2007-4020