Organic Chemistry Portal



Carbonylative Ring Opening of Terminal Epoxides at Atmospheric Pressure

Scott E. Denmark* and Moballigh Ahmad

*Roger Adams Laboratory, Department of Chemistry, University of Illinois, Urbana, Illinois 61801 Email:

S. E. Denmark, M. Ahmad, J. Org. Chem., 2007, 72, 9630-9634.

DOI: 10.1021/jo7014455


A mild, Co2(CO)8-catalyzed carbonylative opening of terminal epoxides under 1 atm of carbon monoxide at room temperature in methanol provides β-hydroxy esters in good yields. This transformation tolerates various functional groups.

see article for more examples

Key Words

carboxylations, β-hydroxy esters

ID: J42-Y2007-4020