gem-Dibromomethylarenes: A Convenient Substitute for Noncommercial Aldehydes in the Knoevenagel−Doebner Reaction for the Synthesis of α,β-Unsaturated Carboxylic Acids
John Kallikat Augustine,* Yanjerappa Arthoba Naik, Ashis Baran Mandal, Nagaraja Chowdappa and Vinuthan B. Praveen
*Syngene International Ltd., Biocon Park, Plot Nos. 2 and 3,
Bommasandra IV Phase, Jigani Link Road, Bangalore-560 100, India, Email:
john.kallikat
syngeneintl.com
J. K. Augustine, Y. A. Naik, A. B. Mandal, N. Chowdappa, V. B. Praveen, J. Org. Chem., 2007, 72, 9854-9856.
DOI: 10.1021/jo701888m
Abstract
gem-Dibromomethylarenes are employed as stable and readily accessible aldehyde equivalents in an efficient Knoevenagel-Doebner reaction with malonic acid to yield α,β-unsaturated carboxylic acids.
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Key Words
Knoevenagel Condensation, Unsatured Carboxylic Acids
ID: J42-Y2007-4110
