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Phosphinous Acid-Catalyzed Cross-Coupling of Aryl Halides and Aryl Grignards

Christian Wolf* and Hanhui Xu

*Department of Chemistry, Georgetown University, Washington, D.C. 20057, Email:

C. Wolf, H. Xu, J. Org. Chem., 2008, 73, 162-167.

DOI: 10.1021/jo701893m (free Supporting Information)


A series of sterically hindered biaryls have been obtained by palladium- and nickel-phosphinous acid-catalyzed Kumada-Corriu cross-coupling of ortho-substituted aryl halides and Grignard reagents. This method allows formation of di- and tri-ortho-substituted biaryls in excellent yield under mild reaction conditions even when electron-rich aryl chlorides are used.

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Key Words

Kumada Coupling

ID: J42-Y2008-0000