A New Reagent System for Efficient Silylation of Alcohols: Silyl Chloride-N-Methylimidazole-Iodine
Agnieszka Bartoszewicz, Marcin Kalek, Johan Nilsson, Renata Hiresova, Jacek Stawinski*
*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 10691 Stockholm, Sweden, Email: jsorgan.su.se
A. Bartoszewicz, M. Kalek, J. Nilsson, R. Hiresova, J. Stawinski, Synlett, 2008, 37-40.
Reactions of alcohols with silyl chlorides in the presence of N-methylimidazole were significantly accelerated by addition of iodine. A general and high yielding method for efficient silylation of primary, secondary, and tertiary alcohols was developed.
see article for more examples
Silyl Ethers, TBDMS-Ethers, TBDPS-Ethers