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A One-Pot, Solid-Phase Synthesis of Secondary Amines from Reactive Alkyl Halides and an Alkyl Azide

Susana Ayesa, Bertil Samuelsson, Björn Classon*

*Medivir AB, P.O. Box 1088, 141 22 Huddinge, Sweden, Email:

S. Ayesa, B. Samuelsson, B. Classon, Synlett, 2008, 89-93.

DOI: 10.1055/s-2007-990927


A polymer-bound, triphenylphosphine-supported reagent allows a one-pot, two-step synthesis of secondary amines from the corresponding azide and a reactive alkyl halide.

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Key Words

secondary amines, azides, phosphinimines, polymer-supported triphenylphosphine, Staudinger reaction

ID: J60-Y2008-0070