A One-Pot, Solid-Phase Synthesis of Secondary Amines from Reactive Alkyl Halides and an Alkyl Azide
Susana Ayesa, Bertil Samuelsson, Björn Classon*
*Medivir AB, P.O. Box 1088, 141 22 Huddinge, Sweden, Email:
bjorn.classon
medivir.se
S. Ayesa, B. Samuelsson, B. Classon, Synlett, 2008, 89-93.
DOI: 10.1055/s-2007-990927
Abstract
A polymer-bound, triphenylphosphine-supported reagent allows a one-pot, two-step synthesis of secondary amines from the corresponding azide and a reactive alkyl halide.
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Key Words
secondary amines, azides, phosphinimines, polymer-supported triphenylphosphine, Staudinger reaction
ID: J60-Y2008-0070
