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Phosphomolybdic Acid: Mild and Efficient Catalyst for Acetylation of Alcohols, Phenols, and Amines under Solvent-Free Conditions

Santosh T. Kadam, Sung Soo Kim*

*Department of Chemistry, Inha University, Incheon 402-751, Korea, Email:

S. T. Kadam, S. S. Kim, Synthesis, 2008, 267-268.

DOI: 10.1055/s-2007-1000859


Phosphomolybdic acid (PMA) is a simple and efficient catalyst for the acetylation of structurally diverse alcohols, phenols, and amines. Acetylation reactions with acetic anhydride proceed in excellent yield in the presence of a catalytic amount of PMA at ambient temperature within a relatively short reaction time under solvent-free conditions.

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Key Words

acetylation (alcohols, amines), acetates, acetamides, phosphomolybdic acid, green chemistry

ID: J66-Y2008-0120