Monosubstituted Malononitriles: Efficient One-Pot Reductive Alkylations of Malononitrile with Aromatic Aldehydes
Fariba Tayyari, Dwight E. Wood, Phillip E. Fanwick, Robert E. Sammelson*
*Department of Chemistry, Ball State University, Muncie, IN
47306-0445, USA,
Email: resammelson
bsu.edu
F. Tayyari, D. E. Wood, P. E. Fanwick, R. E. Sammelson, Synthesis, 2008, 279-285.
DOI: 10.1055/s-2007-990945
Abstract
A powerful one-pot method for the reductive alkylation of stoichiometric amounts of malononitrile with aromatic aldehydes incorporates water as the catalyst in ethanol for the condensation step. The subsequent reduction step takes place quickly and efficiently with sodium borohydride to give monosubstituted malononitriles.
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Key Words
malononitrile, aldehydes, condensation, reduction, sodium borohydride, active methylenes
ID: J66-Y2008-0160
