(BDP)CuH: A “Hot” Stryker's Reagent for Use in Achiral Conjugate Reductions
Benjamin A. Baker, Žarko V. Bošković and Bruce H. Lipshutz*
*Department of Chemistry and Biochemistry, University of
California, Santa Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
B. A. Baker, Ž. V. Bošković, B. H. Lipshutz, Org. Lett., 2008, 10, 289-292.
DOI: 10.1021/ol702689v
Abstract
A ligand-modified, economical version of Stryker's reagent is based on a bidentate, achiral bis-phosphine. Generated in situ, “(BDP)CuH” smoothly effects conjugate reductions of a variety of unsaturated substrates, including those that are normally unreactive toward Stryker's reagent.
see article for more examples
Key Words
Conjugate Reduction, Copper Hydride, PMHS
ID: J54-Y2008-0190
