Mild and General Method for the Synthesis of Sulfonamides
José Luis García Ruano*, Alejandro Parra, Francisco Yuste, Virginia M. Mastranzo
*Departamento de Química Orgánica, Universidad Autónoma de
Madrid, Cantoblanco, 28049 Madrid, Spain,
Email: joseluis.garcia.ruano
uam.es
J. L. C. Ruano, A. Parra, F. Yuste, V. M. Mastranzo, Synthesis, 2008, 311-312.
Abstract
Reaction of methyl sulfinates with lithium amides followed oxidation of the resulting sulfinamides provides primary, secondary, and tertiary alkane-, arene- and heteroarenesulfonamides in high yields. This protocol avoids the use of hazardous, unstable, or volatile reagents and does not affect the configurational stability of the amines.
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Key Words
sulfonamides, oxidation, MCPBA, sulfinamides, methyl sulfinates, chemoselectivity
ID: J66-Y2008-0280
