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Allylic Alkylation and Ring-Closing Metathesis in Sequence: A Successful Cohabitation of Pd and Ru

Claire Kammerer, Guillaume Prestat,* Thomas Gaillard, David Madec and Giovanni Poli*

*UPMC Univ Paris 06, UMR CNRS 7611 Laboratoire de Chimie Organique, FR2769 Institut de Chimie Moléculaire, case183, F-75005, Paris, France, Email: guillaume.prestatupmc.fr, giovanni.poliupmc.fr

C. Kammerer, G. Prestat, T. Gaillard, D. Madec, G. Poli, Org. Lett., 2008, 10, 405-408.

DOI: 10.1021/ol702694v (free Supporting Information)


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Abstract

An allylic alkylation/ring-closing metathesis domino process is catalyzed by the combination of a palladium and a ruthenium catalyst. This study demonstrates the compatibility of the two catalytic systems. Evidence for Grubbs' catalysts activity in allylic alkylation is also reported.

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Key Words

Cyclopentenes, Allylation, Ring Closing Metathesis


ID: J54-Y2008-0290