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An Efficient, One-Pot Synthesis of S-Alkyl Thiocarbamates from the Corresponding Thiols Using the Mitsunobu Reagent

Devdutt Chaturvedi*, Nisha Mishra, Virendra Mishra

*Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India, Email:

D. Chaturvedi, N. Mishra, V. Mishra, Synthesis, 2008, 355-357.

DOI: 10.1055/s-2008-1032025


A mild and efficient Mitsunobu-based protocol has been developed for the synthesis of various S-alkyl thiocarbamates from the corresponding thiols and amines using gaseous carbon dioxide, in good to excellent yields.

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Key Words

thiols, carbon dioxide, Mitsunobu reaction, thiocarbamates

ID: J66-Y2008-0310