Addition of Amines to Nitriles Catalyzed by Ytterbium Amides: An Efficient One-Step Synthesis of Monosubstituted N-Arylamidines
Junfeng Wang, Fan Xu, Tao Cai and Qi Shen*
*Key Laboratory of Organic Synthesis of Jiangsu Province,
Department of Chemistry and Chemical Engineering, Dushu Lake Campus, Suzhou
University, Suzhou 215123, People's Republic of China, Email: qshen
suda.edu.cn
J. Wang, F. Xu, Q. Shen, Org. Lett., 2008, 10, 445-448.
DOI: 10.1021/ol702739c
Abstract
The addition of amines to nitriles catalyzed by ytterbium amides gives monosubstituted N-arylamidinates in good to excellent yields at 100°C under solvent-free conditions.
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ID: J54-Y2008-0330
