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Addition of Amines to Nitriles Catalyzed by Ytterbium Amides: An Efficient One-Step Synthesis of Monosubstituted N-Arylamidines

Junfeng Wang, Fan Xu, Tao Cai and Qi Shen*

*Key Laboratory of Organic Synthesis of Jiangsu Province, Department of Chemistry and Chemical Engineering, Dushu Lake Campus, Suzhou University, Suzhou 215123, People's Republic of China, Email: qshensuda.edu.cn

J. Wang, F. Xu, Q. Shen, Org. Lett., 2008, 10, 445-448.

DOI: 10.1021/ol702739c


Abstract

The addition of amines to nitriles catalyzed by ytterbium amides gives monosubstituted N-arylamidinates in good to excellent yields at 100C under solvent-free conditions.


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Key Words

Amidines


ID: J54-Y2008-0330