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Mild, Rhodium-Catalyzed Intramolecular Hydroamination of Unactivated Terminal and Internal Alkenes with Primary and Secondary Amines

Zhijian Liu and John F. Hartwig*

*Department of Chemistry, University of Illinois Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, Email:

Z. Liu, J. F. Hartwig, J. Am. Chem. Soc., 2008, 130, 1570-1571.

DOI: 10.1021/ja710126x (free Supporting Information)


Mild, rhodium-catalyzed hydroaminations of unactivated olefins with primary and secondary alkylamines form the corresponding five- and six-membered products in excellent yields. A variety of functional groups such as hydroxyl, halo, cyano, and carboalkoxyl groups were tolerated.

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Key Words

Pyrrolidines, Piperidines

ID: J48-Y2008-0370