Organic Chemistry Portal

Abstracts

Search:

Mild, Rhodium-Catalyzed Intramolecular Hydroamination of Unactivated Terminal and Internal Alkenes with Primary and Secondary Amines

Zhijian Liu and John F. Hartwig*

*Department of Chemistry, University of Illinois Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, Email: jhartwiguiuc.edu

Z. Liu, J. F. Hartwig, J. Am. Chem. Soc., 2008, 130, 1570-1571.

DOI: 10.1021/ja710126x (free Supporting Information)


Abstract

Mild, rhodium-catalyzed hydroaminations of unactivated olefins with primary and secondary alkylamines form the corresponding five- and six-membered products in excellent yields. A variety of functional groups such as hydroxyl, halo, cyano, and carboalkoxyl groups were tolerated.

see article for more examples



Key Words

Pyrrolidines, Piperidines


ID: J48-Y2008-0370