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An Efficient Synthesis of Enamides from Ketones

Hang Zhao, Charles P. Vandenbossche, Stefan G. Koenig, Surendra P. Singh* and Roger P. Bakale

*Chemical Process Research and Development, Sepracor Inc., 84 Waterford Drive, Marlborough, Massachusetts 01752, Email:

H. Zhao, C. P. Vandenbossche, S. G. Koenig, S. P. Singh, R. P. Bakale, Org. Lett., 2008, 10, 505-507.

DOI: 10.1021/ol7028788


A new synthesis of enamides from ketones involves a phosphine-mediated reductive acylation of oximes. The resulting enamides are isolated in good yields and excellent purity.

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Key Words

Oximes, Enamides, Triethylphosphine

ID: J54-Y2008-0400