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One-Pot Synthesis of Tetronic Acids from Esters

Aurélie Mallinger, Thierry Le Gall*, Charles Mioskowski

*CEA Saclay, iBiTecS, Service de Chimie Bioorganique et de Marquage, Bât. 547, 91191 Gif-sur-Yvette Cedex, France, Email:

A. Mallinger, T. Le Gall, C. Mioskowski, Synlett, 2008, 386-388.

DOI: 10.1055/s-2008-1032061


Tetronic acids substituted by various groups were synthesized in one pot from the corresponding aryl- or heteroarylacetic acid esters and hydroxyacetic acid esters, by a tandem process involving a transesterification and a subsequent Dieckmann cyclization.

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proposed reaction pathway

Key Words

cyclizations, Dieckmann Condensation, esters, heterocycles, lactones, butenolides, ring closure

ID: J60-Y2008-0410