One-Pot Synthesis of Tetronic Acids from Esters
Aurélie Mallinger, Thierry Le Gall*, Charles Mioskowski
*CEA Saclay, iBiTecS, Service de Chimie Bioorganique et de
Marquage, Bât. 547, 91191 Gif-sur-Yvette Cedex, France, Email: thierry.legall
cea.fr
A. Mallinger, T. Le Gall, C. Mioskowski, Synlett, 2008, 386-388.
DOI: 10.1055/s-2008-1032061
Abstract
Tetronic acids substituted by various groups were synthesized in one pot from the corresponding aryl- or heteroarylacetic acid esters and hydroxyacetic acid esters, by a tandem process involving a transesterification and a subsequent Dieckmann cyclization.
see article for more examples
proposed reaction pathway
Key Words
cyclizations, Dieckmann Condensation, esters, heterocycles, lactones, butenolides, ring closure
ID: J60-Y2008-0410
