One-Pot Synthesis of Tetronic Acids from Esters
Aurélie Mallinger, Thierry Le Gall*, Charles Mioskowski
*CEA Saclay, iBiTecS, Service de Chimie Bioorganique et de Marquage, Bât. 547, 91191 Gif-sur-Yvette Cedex, France, Email: thierry.legallcea.fr
A. Mallinger, T. Le Gall, C. Mioskowski, Synlett, 2008, 386-388.
Tetronic acids substituted by various groups were synthesized in one pot from the corresponding aryl- or heteroarylacetic acid esters and hydroxyacetic acid esters, by a tandem process involving a transesterification and a subsequent Dieckmann cyclization.
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proposed reaction pathway