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Oxygen and Base-Free Oxidative Heck Reactions of Arylboronic Acids with Olefins

Jiwu Ruan, Xinming Li, Ourida Saidi and Jianliang Xiao*

*Department of Chemistry, Liverpool Centre for Materials and Catalysis, University of Liverpool, Liverpool L69 7ZD, U.K., Email:

J. Ruan, X. Li, O. Saidi, J. Xiao, J. Am. Chem. Soc., 2008, 130, 2424-2425.

DOI: 10.1021/ja0782955 (free Supporting Information)


A mild and efficient protocol for palladium-catalyzed oxidative Heck reactions of arylboronic acids with both electron-rich and -deficient olefins works in the absence of a base, oxygen, or other external oxidants. With a wide variety of substrates tolerated, the method broadens the scope of palladium-catalyzed coupling reactions.

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Key Words

Aryl Ketones, Olefinations

ID: J48-Y2008-0470