Gold(III)-Catalyzed Cyanosilylation of Ketones and Aldehydes
Woo Kyung Cho, Sung Min Kang, Amiya K. Medda, Jungkyu K. Lee, Insung S. Choi*, Hee-Seung Lee*
*Department of Chemistry and School of Molecular Science (BK21), Center for Molecular Design and Synthesis, KAIST, Daejeon 305-701, Korea, Email: ischoikaist.ac.kr, hee-seung_leekaist.ac.kr
W. K. Cho, S. M. Kang, A. K. Medda, J. K. Lee, I. S. Choi, H.-S. Lee, Synthesis, 2008, 507-510.
Gold(III) chloride is a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only 1 mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields.
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cyanohydrins, transition metals, homogeneous catalysis, ketones, aldehydes