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Gold(III)-Catalyzed Cyanosilylation of Ketones and Aldehydes

Woo Kyung Cho, Sung Min Kang, Amiya K. Medda, Jungkyu K. Lee, Insung S. Choi*, Hee-Seung Lee*

*Department of Chemistry and School of Molecular Science (BK21), Center for Molecular Design and Synthesis, KAIST, Daejeon 305-701, Korea, Email:,

W. K. Cho, S. M. Kang, A. K. Medda, J. K. Lee, I. S. Choi, H.-S. Lee, Synthesis, 2008, 507-510.

DOI: 10.1055/s-2008-1032154


Gold(III) chloride is a highly efficient catalyst for the cyanosilylation of various ketones and aldehydes. The reactions were complete within 30 minutes at room temperature in the presence of only 1 mol% gold(III) chloride, yielding the corresponding cyanohydrin trimethylsilyl ethers in very good yields.

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Key Words

cyanohydrins, transition metals, homogeneous catalysis, ketones, aldehydes

ID: J66-Y2008-0510