One-Pot Synthesis of 1,4-Dihydropyridines via a Phenylboronic Acid Catalyzed Hantzsch Three-Component Reaction
Abdelmadjid Debache*, Raouf Boulcina, Ali Belfaitah, Salah Rhouati, Bertrand Carboni
*Laboratoire des Produits Naturels d'Origine Végétale et de Synthèse Organique, Département de Chimie, Faculté des Sciences, Université Mentouri de Constantine, 25000 Constantine, Algérie, Email: a_debacheyahoo.fr
A. Debache, R. Boulcina, A. Belfaitah, S. Rhouati, B. Carboni, Synlett, 2008, 509-512.
DOI: 10.1055/s-2008-1032093
Abstract
A simple, inexpensive, and efficient one-pot synthesis of 1,4-dihydropyridine derivatives was achieved in good yields via the three-component reaction of aromatic aldehydes, ethyl acetoacetate, and ammonium acetate using PhB(OH)2 as catalyst.
see article for more examples
Key Words
1,4-dihydropyridines, Hantzsch reaction, one-pot condensation, multicomponent reactions, phenylboronic acid
ID: J60-Y2008-0540