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Synthesis of Highly Functionalized Pyrrole Derivatives via a Four-Component Reaction of Two Primary Amines and Diketene in the Presence of Nitrostyrene

Abdolali Alizadeh*, Atieh Rezvanian, Hamid R. Bijanzadeh

*Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran 18716, Iran, Email: aalizadehmodares.ac.ir

A. Alizadeh, A. Rezvanian, H. R. Bijanzadeh, Synthesis, 2008, 725-728.

DOI: 10.1055/s-2008-1032168


Abstract

The reaction of an enaminone, which can be derived from two primary amines and diketene, in the presence of nitrostyrene gives functionalized pyrrole derivatives in very good yields.

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A New Method for the Synthesis of Functionalized 5-Hydroxy-1,5-dihydro-2H-pyrrol-2-one: Reaction of an Enamine, Derived from Addition of a Secondary­ Amine to Dibenzoylacetylene, with an Arylsulfonyl Isocyanate

A. Alizadeh, F. Movahedi, H. Masrouri, L.-G. Zhu, Synthesis, 2006, 3431-3436.


Key Words

amines, diketenes, enaminones, nitrostyrene, pyrroles


ID: J66-Y2008-0580