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Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters

Xing Dai, Neil A. Strotman and Gregory C. Fu*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

X. Dai, N. A. Strotman, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 3302-3303.

DOI: 10.1021/ja8009428


A catalytic asymmetric cross-coupling of α-halo carbonyl compounds with aryl metal reagents generates synthetically useful α-aryl carboxylic acid derivatives in good enantiomeric excess. The method can also be applied to enantioselective alkenylation reactions.

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Key Words

α-Arylation, Alkenylation, Hiyama Coupling

ID: J48-Y2008-0660