Catalytic Asymmetric Hiyama Cross-Couplings of Racemic α-Bromo Esters
Xing Dai, Neil A. Strotman and Gregory C. Fu*
*Department of Chemistry, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139, Email: gcf
mit.edu
X. Dai, N. A. Strotman, G. C. Fu, J. Am. Chem. Soc., 2008, 130, 3302-3303.
DOI: 10.1021/ja8009428
Abstract
A catalytic asymmetric cross-coupling of α-halo carbonyl compounds with aryl metal reagents generates synthetically useful α-aryl carboxylic acid derivatives in good enantiomeric excess. The method can also be applied to enantioselective alkenylation reactions.
see article for more examples
Key Words
α-Arylation, Alkenylation, Hiyama Coupling
ID: J48-Y2008-0660
