Synthesis of Dihydropyridines and Pyridines from Imines and Alkynes via C-H Activation
Denise A. Colby, Robert G. Bergman* and Jonathan A. Ellman*
*Department of Chemistry, University of California, and Division of Chemical Sciences, Lawrence Berkeley National Laboratory, Berkeley, California, 94720, Email: rbergmanberkeley.edu, jellmanuclink.berkeley.edu
D. A. Colby, R. G. Berman, J. A. Ellman, J. Am. Chem. Soc., 2008, 130, 3645-3651.
DOI: 10.1021/ja7104784 (free Supporting Information)
A convenient one-pot C-H alkenylation/electrocyclization/aromatization sequence allows the synthesis of highly substituted pyridine derivatives from alkynes and α,β-unsaturated N-benzyl aldimines and ketimines. The reaction proceeds through dihydropyridine intermediates.
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