Highly Enantioselective Aryl Transfer to Aldehydes: A Remarkable Effect of Sulfur Substitution in Amino Thioacetate Ligands
Myung-Jong Jin,* Shaheen M. Sarkar, Dong-Hwan Lee and Huili Qiu
*School of Chemical Science and Engineering, Inha University, Incheon 402-751, South Korea, Email: mjjininha.ac.kr
M.-J. Jin, S. M. Sarkar, D.-H. Lee, H. Qiu, Org. Lett., 2008, 10, 1235-1237.
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Chiral amino thioacetate ligands were remarkably superior to the corresponding amino alcohols as catalysts for enantioselective aryl transfer reactions. Low catalyst loadings were sufficient to achieve excellent enantioselectivity as well as high conversion in short reaction time.
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