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Direct Asymmetric Iodination of Aldehydes Using an Axially Chiral Bifunctional Amino Alcohol Catalyst

Taichi Kano, Mitsuhiro Ueda and Keiji Maruoka*

*Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan, Email:

T. Kano, M. Ueda, K. Maruoka, J. Am. Chem. Soc., 2008, 130, 3728-3729.

DOI: 10.1021/ja074003o


A direct asymmetric iodination reaction of aldehydes with NIS catalyzed by a novel axially chiral bifunctional amino alcohol represents a rare example of a highly enantioselective synthesis of optically active α-iodoaldehydes.

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Key Words

α-Iodination, NIS, Organocatalysis

ID: J48-Y2008-0790