Direct Asymmetric Iodination of Aldehydes Using an Axially Chiral Bifunctional Amino Alcohol Catalyst
Taichi Kano, Mitsuhiro Ueda and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto
University, Sakyo, Kyoto 606-8502, Japan, Email: maruoka
kuchem.kyoto-u.ac.jp
T. Kano, M. Ueda, K. Maruoka, J. Am. Chem. Soc., 2008, 130, 3728-3729.
DOI: 10.1021/ja074003o
Abstract
A direct asymmetric iodination reaction of aldehydes with NIS catalyzed by a novel axially chiral bifunctional amino alcohol represents a rare example of a highly enantioselective synthesis of optically active α-iodoaldehydes.
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Key Words
α-Iodination, NIS, Organocatalysis
ID: J48-Y2008-0790
