Synthesis of Functionalized Enamines: A Facile and Efficient Protocol toward N-Protected α,β-Dehydroamino Acid Derivatives
Yun Sun, Xiaozhao Wang, Xiufang Zheng, Kang Zhao*
*Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, P. R. of China, Email: kangzhaotju.edu.cn
Y. Sun, X. Wang, X. Zheng, K. Zhao, Synlett, 2008, 861-866.
see article for more reactions
α,β-Dehydroamino acid derivatives were synthesized in good yields from α-bromoketones or α-bromoesters and hydroxamates via a sequential procedure involving displacement of bromide by hydroxamate anion, followed by a base-induced elimination-isomerization reaction.
see article for more examples