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Efficient Synthesis of Hantzsch Esters and Polyhydroquinoline Derivatives in Aqueous Micelles

Atul Kumar*, Ram Awatar Maurya

*Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India, Email:

A. Kumar, R. A. Maurya, Synlett, 2008, 883-885.

DOI: 10.1055/s-2008-1042908


Hantzsch 1,4-dihydropyridine and polyhydroquinoline derivatives were synthesized in excellent yields in aqueous micelles. The reaction is catalyzed by PTSA and strongly accelerated by ultrasonic irradiation.

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Key Words

Hantzsch esters, Hantzsch Synthesis, polyhydroquinoline derivatives, aqueous micelles, PTSA, Green Chemistry, multicomponent reactions, sonochemistry

ID: J60-Y2008-0870