Zinc-Catalyzed Silylation of Terminal Alkynes
Ronald J. Rahaim, Jr. and Jared T. Shaw*
*Broad Institute of Harvard and MIT Program in Chemical
Biology, 7 Cambridge Center, Cambridge, Massachusetts 02142, Email: shaw
chem.ucdavis.edu
R. J. Rahaim, Jr., J. T. Shaw, J. Org. Chem., 2008, 73, 2912-2915.
DOI: 10.1021/jo702557d
Abstract
A rapid and high-yielding silylation of terminal alkynes employing TMSOTf and catalytic quantities of Zn(OTf)2 works well for a variety of substrates including reactive esters.
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Key Words
ID: J42-Y2008-1030
