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Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates

Jhillu S. Yadav*, Basi V. Subba Reddy, Ummareddy V. Subba Reddy, Darshanoju N. Chary

*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email:

J. S. Yadav, B. V. S. Reddy, U. V. S. Reddy, D. N. Chary, Synthesis, 2008, 1283-1287.

DOI: 10.1055/s-2008-1072517


A simple and efficient FeCl3-mediated method for the α-thiocyanation of ketones produces α-oxo thiocyanates in very good yields and with high selectivity under mild conditions. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient and practical.

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Ferric(III) Chloride-Promoted Efficient Thiocyanation of Arylalkenes: A Facile Synthesis of Dithiocyanates

J. S. Yadav, B. V. S. Reddy, M. K. Gupta, Synthesis, 2004, 1983-1986.

Key Words

thiocyanation, ketones, iron(III) chloride, catalysis, α-oxo thiocyanates

ID: J66-Y2008-1040