Iron(III) Chloride as Mild and Efficient Reagent for the α-Thiocyanation of Ketones: An Expedient Synthesis of α-Oxo Thiocyanates
Jhillu S. Yadav*, Basi V. Subba Reddy, Ummareddy V. Subba Reddy, Darshanoju N. Chary
*Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Email: yadaviict.res.in
J. S. Yadav, B. V. S. Reddy, U. V. S. Reddy, D. N. Chary, Synthesis, 2008, 1283-1287.
DOI: 10.1055/s-2008-1072517
Abstract
A simple and efficient FeCl3-mediated method for the α-thiocyanation of ketones produces α-oxo thiocyanates in very good yields and with high selectivity under mild conditions. The use of inexpensive and readily available iron(III) chloride makes this procedure simple, convenient and practical.
see article for more examples
J. S. Yadav, B. V. S. Reddy, M. K. Gupta, Synthesis, 2004, 1983-1986.
Key Words
thiocyanation, ketones, iron(III) chloride, catalysis, α-oxo thiocyanates
ID: J66-Y2008-1040