Palladium-Catalyzed α-Arylation of Esters with Chloroarenes
Takuo Hama and John F. Hartwig*
*Department of Chemistry, University of Illinois Urbana-Champaign, Box 58-6, Urbana, Illinois 61801, Email: jhartwiguiuc.edu
T. Hama, J. F. Hartwig, Org. Lett., 2008, 10, 1549-1552.
DOI: 10.1021/ol800258u
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Abstract
Palladium-catalyzed α-arylations of chloroarenes with the sodium enolates of tert-butyl propionate and methyl isobutyrate occur in high yields using P(t-Bu)3 as ligand. The reactions of chloroarenes with the Reformatsky reagent of tert-butyl acetate were most challenging but occurred in high yields for chlorobenzene and electron-poor chloroarenes.
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M. Jørgensen, S. Lee, X. Liu, J. P. Wolkowski, J. F. Hartwig, J. Am. Chem. Soc., 2002, 124, 12557-12565.
Key Words
ID: J54-Y2008-1050