Silica-Supported Tetramethylguanidine: An Efficient Solid Base for Aldol-Type Coupling of Aldehydes with Ethyl Diazoacetate
Pravin R. Likhar*, Sarabindu Roy, Moumita Roy, M. S. Subhas, M. Lakshmi Kantam
*Indian Institute of Chemical Technology, Inorganic & Physical Chemistry Division, Hyderabad 500007, India, Email: plikhariict.res.in
P. R. Likhar, S. Roy, M. Roy, M. S. Subhas, M. Lakshmi Kantam, Synlett, 2008, 1283-1286.
Silica-supported tetramethylguanidine catalyst was prepared and effectively used in the aldol-type coupling of aldehydes with ethyl diazoacetate to afford the corresponding α-diazo-β-hydroxy esters in very good yields. The catalyst can be reused for a number of cycles with almost consistent activity by a simple filtration.
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