Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes
Gaëlle Le Bras, Abdallah Hamze, Samir Messaoudi, Olivier Provot*, Pierre-Benoît Le Calvez, Jean-Daniel Brion, Mouâd Alami*
*Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie,
Université Paris-Sud XI, CNRS, BioCIS, UMR 8076, rue J. B. Clément, 92296
Châtenay-Malabry, France, Email: olivier.provot
u-psud.fr,
mouad.alamiu-psud.fr
G. Le Bras, A. Hamze, S. Messaoudi, O. Provot, P.-B. Le Calvez, J.-D. Brion, M. Alami, Synthesis, 2008, 1607-1611.
DOI: 10.1055/s-2008-1072575
Abstract
p-Toluenesulfonic acid (PTSA) in ethanol was used as a mild acid catalyst for the annulation of various functionalized diarylalkynes under microwave irradiation. This metal-free process allowed the synthesis of various 3-aryl-substituted isocoumarins in good yields.
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Key Words
alkynes, annulations, isocoumarins, isochromenes, microwave synthesis
ID: J66-Y2008-1310
