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Room-Temperature Kumada Cross-Coupling of Unactivated Aryl Chlorides Catalyzed by N-Heterocylic Carbene-Based Nickel(II) Complexes

Zhenxing Xi, Bin Liu and Wanzhi Chen*

*Department of Chemistry, Zhejiang University, Xixi Campus, Hangzhou 310028, P. R. China, Email:

Z. Xi, B. Liu, W. Chen, J. Org. Chem., 2008, 73, 3954-3957.

DOI: 10.1021/jo800197u (free Supporting Information)


The Kumada cross-coupling reaction of various unactivated aryl chlorides, vinyl chlorides, and heteroaryl chlorides catalyzed by very active nickel(II) complexes containing pyridine-functionalized NHC ligands proceeds at room temperature in excellent yields.

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Key Words

Kumada Coupling

ID: J42-Y2008-1330