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An Easy Microwave-Assisted Synthesis of Sulfonamides Directly from Sulfonic Acids

Lidia De Luca and Giampaolo Giacomelli*

*Dipartimento di Chimica, UniversitÓ degli Studi di Sassari,Via Vienna 2, I-07100 Sassari, Italy, Email:

L. De Luca, G. Giacomelli, J. Org. Chem., 2008, 73, 3967-3969.

DOI: 10.1021/jo800424g


An easy and handy synthesis of sulfonamides directly from sulfonic acids or its sodium salts is performed under microwave irradiation, has shown a good functional group tolerance, and is high yielding.

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Key Words

Sulfonamides, Toluenesulfonamides, Microwave Synthesis

ID: J42-Y2008-1350